Janssen Research & Development, L.L.C., a division of Johnson & Johnson’s Family of Companies is recruiting for a Scientist, Multispecific Antibody & Chimeric Antigen Receptor Engineering located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Protein Engineering and In Vitro Discovery Team within Biologics Discovery is responsible for the design of lead biologic candidates. In this position, the Scientist will be an integral member of the technology savvy Multispecific Antibody and CAR Design Group that delivers “Therapeutic Design Fit-for-Purpose” into the pipeline. The position offers an exciting opportunity to not only engage in the discovery and molecular engineering of biotherapeutics, but also develop new processes and technologies for therapeutic discovery. This Scientist will have the opportunity to lead project teams to interact seamlessly with world-class Therapeutic Area scientists.

Key Responsibilities:

• Lead/participate on project teams to advance discovery portfolio projects.
• Champion technology development efforts aimed at fulfilling strategic long-term antibody design initiatives and validation.
• Independently present/defend scientific findings in multi-functional project teams/initiatives.
• Independently plan, analyze and interpret experimental results and draft patent applications, manuscripts, protocols, SOPs, technical reports, etc.

Qualifications

Education:

• Ph.D. in structural biology, biochemistry, biophysics or a related field with at least 1 year of experience is required.

Experience and Skills:

Required:

• In-depth knowledge of protein structure and analysis, including structure determination methods (e.g. x-ray crystallography, cryo-electron microscopy, NMR, or computational methods) and structure-based protein design is required.
• Sound understanding of biophysical and biochemical methods for protein analysis, including ELISA, SPR, and/or flow cytometry, thermal stability analysis, and protein expression/purification from mammalian and bacterial cells is required.
• Expertise in protein structure modeling and analysis (e.g. Schrodinger, MOE, pyMol, etc.) is required.
• Detailed knowledge of molecular biology, including expression vector design, protein expression from mammalian host cells and purification (affinity chromatography, ion-exchange chromatography, etc) is required.
• Zeal for stepping out of the box and a collaborative spirit with demonstration of successful implementation of new ideas with calculated risk taking. Abilities to lead by influence and communicate across teams with diverse backgrounds is required.
• Demonstration of clear, concise, and timely communication skills, exemplified by peer-reviewed publications is required.
• Experience with of the state-of-the-art molecular biology and protein engineering methods, including antibody, cytokine, or chimeric antigen receptor (CAR) design, is required.
• Hands on experience in protein expression mammalian host cells and purification (affinity chromatography, ion-exchange chromatography, etc) is required.
• Detailed understanding of antibody sequence analysis, including post-translational modification risks, germline analysis, and Fc-mediated effector functions is required.

Preferred:

• A minimum of 1 year of industry experience is preferred.
• Expertise in scientific computing (e.g. Python) is preferred.
• Understanding of antibody, cytokine, or chimeric antigen receptor (CAR) structure and function, including modulation of target binding and Fc-based effector function is preferred.
• Scientific computing/in silico protein structure analysis is preferred.
• Hands on experience in HTP-based binding assays (such as ELISA, SPR, MSD) and/or cell-based (Intellicyt/iQue) for screening antibody variants is preferred.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit www.careers.jnj.com.